sumoylation by ranbp2 regulates transcriptional repression
| PAG Title | sumoylation by ranbp2 regulates transcriptional repression |
| PAG ID | WAG001452 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Current data indicates that nuclear pore complex (NPC) RanBP2 (SUMO E3 ligase) protein sumoylates Mdm2 and HDAC proteins during nuclear translocation. A sumoylation-deficient HDAC showed reduced deacetylation activity and suggests that sumoylation may be an important regulatory mechanism for the control of transcriptiol repression. |
| Species | Homo sapiens |
| nCoCo Score | 2,928 |
| Base PAG ID | WAG001452 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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